The United States New Psychedelic Renaissance begins with Oregon voters passing Ballot Measure 109 in 2020, which legalized the therapeutic use of psilocybin with a licensed facilitator. Colorado legalized psychedelics, namely Psilocybin, DMT, Mescaline and Ibogaine in the November 2022 elections.

Psychedelic ecosystem expands beyond medical applications and it is notable that Indigenous communities have used psychedelic plants and fungi for ceremonial and sacramental purposes for millennia. Under the United States Religious Freedom Restoration Act, the Native American Church, which has over 250,000 members, is legally permitted to use peyote, and the União do Vegetal church is legally permitted to consume DMT-containing brew ayahuasca as sacraments.

Connecticut and Texas are also exploring legislation to study medical risks and benefits of psilocybin, and California Senate Bill 519, which proposes the decriminalization of psilocybin, MDMA, LSD, mescaline, ibogaine and Ayahuasca (DMT) for personal use and social sharing, cleared early hurdles in August 2021 and will be voted on in 2022.

Other areas in the country which have decriminalized Psilocybin include Washington DC, Denver, Oakland, Ann Arbor, Houston, Somerset and Cambridge, MA, Detroit MI, and San Francisco, CA.